In the LUSC cases, 2 [glutathione S-transferase alpha 1 (GSTA1) and hyaluronan synthase 1(HAS1)] of the 3 validated genes have been reported to play important roles in the process of cancer development, and the third gene [leucine-rich repeat LGI family member 2 (LGI2)] has never before been studied in detail. The gene discussed is LGI2; the disease is cancer.