BTK and cancer: For example, 7 of the LUAD-associated genes [intercellular adhesion molecule 3 (ICAM3), membrane spanning 4-domains A1 (MS4A1), IL-16, Bruton tyrosine kinase (BTK), kallikrein-related peptidase 12 (KLK12), tumor necrosis factor superfamily member 8 (TNFSF8), and CCR2] had already been reported to participate in the progression of other cancers, whereas the functions of the other 16 genes have never before been reported in any cancers.