For example, 7 of the LUAD-associated genes [intercellular adhesion molecule 3 (ICAM3), membrane spanning 4-domains A1 (MS4A1), IL-16, Bruton tyrosine kinase (BTK), kallikrein-related peptidase 12 (KLK12), tumor necrosis factor superfamily member 8 (TNFSF8), and CCR2] had already been reported to participate in the progression of other cancers, whereas the functions of the other 16 genes have never before been reported in any cancers. This evidence concerns the gene TNFSF8 and cancer.