For example, the release of oxidized HMGB1 by cancer cells undergoing pyroptosis, a gasdermin-dependent form of RCD generally associated with inflammasome activation,1 limits anticancer immunity as it favors the expression of coinhibitory ligands.236 In contrast, oxidized mitochondrial DNA favors inflammasome activation and hence the secretion of immunostimulatory factors such as IL-1β in the TME,237 although the actual pathologic relevance of this pathway remains unknown. The gene discussed is HMGB1; the disease is cancer.