CCL2 and cancer: CXCL10 then acts as a chemoattractant for T cells and, together with CXCL1 and CCL2, for neutrophils, which (at least in some settings) appear to contribute to the ICD-driven killing of residual cancer cells in an antigen-independent fashion.151 158 Of note, cancer cell-derived nucleic acids can also mediate immunostimulatory effects by driving type I IFN secretion in APCs, generally on the transfer of nucleic acid-containing extracellular microvesicles between these two cellular compartments.195 197