We have shown previously that macrophage transition from G0 to a G1-like state is accompanied by an increase in certain cell-cycle-associated proteins, such as MCM2 and CDK1, as well as phosphorylation of SAMHD1 at T592 that confers increased susceptibility to HIV-1 infection (Mlcochova et al., 2017, Mlcochova et al., 2018). This evidence concerns the gene MCM2 and HIV-1 infection.