Whilst speculative, it is also potentially of relevance that HTR1A protein expression is upregulated in the brains of schizophrenics (Carrard et al., 2011) and variants in both HTR1A and SLIT3 are associated with psychiatric disorders (Shi et al., 2004; Glessner et al., 2010; Cukier et al., 2014), known to involve dopaminergic and serotoninergic pathways. This evidence concerns the gene HTR1A and psychiatric disorder.