Notably, the proteins induced with loss of DDX39B act to promote angiogenesis, cell migration, and interaction with the ECM (e.g., VEGF, uPA, IL6, PTX3, and PDGFB), supporting the mRNA data and indicating that in GBM cells, DDX39B attenuates expression of secreted factors that are associated with these processes. The gene discussed is PLAU; the disease is glioblastoma.