Even though the inverse correlations between CXCL13 and eosinophils and basophils were surprising, tissue eosinophils have been shown to produce CXCL13 or induce its expression in macrophages during inflammation in mice [43, 44], suggesting that the sequestration of eosinophils in tissues could promote the production of CXCL13 in tissue macrophages during hyperacute HIV infection. This evidence concerns the gene CXCL13 and HIV infectious disease.