SFTPC and infection: Upon intranasal infection of mice with a low lethal dose of 3.5 LD50 mouse-adapted PR8 (A/PuertoRico/8/34 H1N1), Spc-Cre+.Hif1αfl/fl mice showed increased mortality (Figure 1(A)) and weight loss (Figure 1(B)) compared to the PR8-infected control mice.