ENTPD1 and neoplasm: The extracellular ATP can be degraded into adenosine by ectonucleotidases (CD39 and CD73).33 These adenosines bind to the adenosine receptors, such as A1R, A2AR, A2BR and A3R to induce the downstream regulation and mediate a series of protumor and immunosuppressive effects.33 These adenosine receptors, CD39 and CD73, which are termed as “adenosinergic molecules,” are expressed on the plasma membrane of various cell types, including the tumor, stromal and immune cells.33 Adenosine can directly or indirectly suppress the T‐cell function.