AKT1 and ovarian cancer: The ovarian cancer cells derived from the ascites are reported to constitutively secrete functional Fas ligand, which can induce apoptosis of the CD95/Fas‐positive immune cells.9 Some factors of the malignant ascites can activate the PI3K/AKT signaling pathway through αvβ5 integrin on the ovarian cancer cells and subsequently inhibit TRAIL‐induced apoptosis of tumor cells.10, 11 This is another mechanism for the tumor to escape the immune response.