We tested if TFEB can clear following types of p-Tau: (1) 0N3R –non-mutant tau, when over-expressed can lead to Pick’s Disease (PiD) [56], (2) 0N3R (T231D/S235D) tau, which mimics hyperphosphorylation on T231/S335 sites and is known to disrupt tau’s interaction with microtubules [57], (3) 0N4R –non-mutant tau, but over-expression can lead to progressive supranuclear palsy (PSP) [58], and (4) 0N4R-P301L mutant tau, which cause FTDP-17T [59,60]. Here, MAPT is linked to supranuclear palsy, progressive, 1.