Those who with genetic predisposition to AD, including Marfan syndrome, Loeys-Dietz syndrome and other forms of familial thoracic aortic aneurysm/dissection, may benefit from MRTF-A inhibition for preventing the development of life-threatening AD. The gene discussed is MRTFA; the disease is marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections.