CASP8 and cancer: In addition, it has been reported by strong evidence that miR-let-7a targeted genes in several types of cancer, for instance, CASP8, BCL2, CCND2, EWSR1, FOXA1, DICER1, HMGA1, HMGA2, KRAS, MYC, HRAS, MPL, NF2, PRDM1, NRAS [39]34 and COSMIC [40].