Cushing’s disease (CD), or pituitary-dependent Cushing's syndrome (CS) is a rare clinical syndrome, estimated incidence of 2.4 new cases per million inhabitants per year, and is characterized by excessive endogenous exposure to glucocorticoids (GCs), due to an adrenocorticotropic hormone (ACTH) secreting pituitary adenoma [1]. This evidence concerns the gene POMC and Cowden syndrome 1.