As inhibiting MMP activity could greatly stabilize aneural AChR clusters against spontaneous and nerve-induced dispersal (Figure 2I and Figure 7D), it would be interesting to test if manipulating muscle MT1-MMP expression level or its activity can suppress the pathogenic action in causing NMJ disassembly using our recently established Xenopus cell-based assay for investigating the pathogenesis of myasthenia gravis (Chan et al., 2017; Yeo et al., 2015). Here, MMP14 is linked to myasthenia gravis.