H19 and colorectal carcinoma: Li et al31 observed that the A allele of rs2839698 polymorphism increased the risk of CRC and this SNP may change the crucial folding structures and the target microRNAs of H19. This present study showed H19 gene rs2839698 polymorphism was associated with a deceased risk of CRC, which was different from the study by Li et al We thought the inconsistency may be attributed to four reasons.