KCNE1 and long QT syndrome 5: In the case of IKs (Kv7.1/KCNE1) currents, PUFA analogues would rescue loss-of-function mutants of Kv7.1/KCNE1 (IKs) channels in LQT1 (KCNQ1 mutations) or LQT5 (KCNE1 mutations).