In the case of IKs (Kv7.1/KCNE1) currents, PUFA analogues would rescue loss-of-function mutants of Kv7.1/KCNE1 (IKs) channels in LQT1 (KCNQ1 mutations) or LQT5 (KCNE1 mutations). The gene discussed is KCNE1; the disease is long QT syndrome 1.