F9 and hemophilia B: The initial work on this system showed the ability insert the cDNA and a number of proteins including Factor IX (hemophilia B), Factor VIII (hemophilia A), α-Galoactosidase A (Fabry Disease), α-l-Iduronidase (Hurler Syndrome, a.k.a. mucopolysaccharidosis type I (MPS I)), Iduronate-2 Sulfatase (Hunter Syndrome, a.k.a. mucopolysaccharidosis type II (MPS II)), and Acid β-Glucosidase (Gaucher Disease) [92].