Receptors consist of extracellular, transmembrane, and intracellular domains.8FGFR1 play key roles in proliferation, differentiation, and migration in healthy cells through MAPK/ERK, PI3K/AKT, and JAK‐STAT pathways.9, 10 Malfunction of FGFR1 signaling usually result from point mutations, gene amplification, or fusions.9, 11 Over‐activation of FGFR1 signaling is tumorigenic via promoting proliferation, angiogenesis, and antiapoptotic roles in blood, bladder, gastric, breast, and prostate cancers.9, 12, 13, 14, 15. Here, FGFR1 is linked to Familial prostate cancer.