This correlation is interesting knowing that Her2 target in breast cancer, in some cases, has shown no correlation between overexpression and amplification.45, 46 Previous studies have shown controversial findings regarding association between FGFR1 amplification and mRNA/protein expression.20, 47, 48 In this regard, our analysis of 129 SQCLC and 36 SCLC patients revealed no significant correlation between FGFR1 amplification and protein expression (P = .54 in SQCLC and P = .99 in SCLC). This evidence concerns the gene ERBB2 and breast cancer.