Because macrolide and colchicine are metabolized through CYP3A4, co‐administration of these two agents can cause fatal toxicity, such as pancytopenia, rhabdomyolysis or even multiorgan failure.22, 23 Lastly, dapsone is also not a preferred option because the patients are usually anemic. The gene discussed is CYP3A4; the disease is Pancytopenia.