Ironically, adequately powered and designed studies of CETP genetic variation have simultaneously established the non-causal nature of the circulating HDL-C -> CHD association and have demonstrated that any effect of CETP inhibition on CHD is due to its (small) Apo B and LDL cholesterol lowering—rather than its substantial HDL-C elevating—effect [98, 99]. Here, CETP is linked to coronary artery disorder.