Lafutidine and roxatidine belongs to second-generation histamine H2 receptor antagonists with fewer side effects, whereas cimetidine, ranitidine and famotidine comprise the first-generation.35 However, further studies would be required to shed more lights on the management of NSAIDs-induced intestinal ulcer by histamine H2 receptor antagonists. This evidence concerns the gene HRH2 and intestinal disorder.