One ofthe neurotrophins in the BDNF, which facilitates the growth and sustainability ofnerve cells, modulates synapse response and is responsible for synapseplasticity.24 A recent study showed thatfailure of synapse neuroplasticity (neurogenesis, axon branching, dendritogenesis,and synaptogenesis) in particular regions of the brain, especially the hippocampus,is the main pathophysiological factor in depression. The gene discussed is BDNF; the disease is major depressive disorder.