EGF and Alzheimer disease: Patients with AD present increased IL-1β, IL-2, IL-6, IL-18, soluble TNF-receptor (sTNF-R) 1 and 2, high sensitivity CPR (hsCPR), interferon (IFN) – γ, C-X-C motif chemokine (CXCL) – 10, epidermal growth factor (EGF), vascular cell adhesion molecule (VCAM) – 1, α1-antichymotrypsin and transferrin compared to age-matched controls.40 These mediators might play a direct role on cognition.