In the study of Shrypek et al., the expression of MUC4 in pancreatic cancer cells led to a marked decrease in hCNT1 and hCNT3 transporters which lead gemcitabine inside the tumoral cells, so the expression of this protein could be investigated as potential predictive marker of resistance to chemotherapy regimen containing gemcitabine [123]. This evidence concerns the gene MUC4 and pancreatic neoplasm.