They also report that miR-125a transfection was associated with down-regulation of phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) messenger RNA expression, suggesting that miR-125a exerts tumor suppressive effects by targeting the PI3K/AKT/mTOR pathway [35]. The gene discussed is MTOR; the disease is neoplasm.