In human HCC tissues from two independent cohorts of patients, HOXC10 expression was positively correlated with PDPK1 and VASP expression, and patients with positive coexpression of HOXC10/PDPK1 or HOXC10/VASP showed the poorest overall survival and highest recurrence rate. Here, PDPK1 is linked to hepatocellular carcinoma.