We found that knockdown of CAMSAP2 in MHCC97H cells significantly increased HDAC6 expression, whereas HDAC6 was markedly downregulated in Huh7-Lv-CAMSAP2 cells with no apparent change in the expression of αTAT1 in the transfected HCC cells. Here, HDAC6 is linked to hepatocellular carcinoma.