Bioluminescence imaging of the HCC cells prior to orthotopic implantation is shown in Figure S3A. Consistent with the in-vitro results, CAMSAP2 upregulation significantly increased intrahepatic and lung metastases, resulting in a shorter OS time of the Huh7-Lv-CAMSAP2 compared with the control group (Figure 2E-F). The gene discussed is CAMSAP2; the disease is hepatocellular carcinoma.