Furthermore, circ-Amotl1 recruits the Signal Transducer and Activator of Transcription 3 (STAT3) from the cytoplasm to the nucleus and stabilizes its binding to the Dnmt3a promoter 93, while circMYBL2 regulates FMS-Like Tyrosine kinase-3 (FLT3) translation by recruiting Polypyrimidine Tract-Binding Protein 1 (PTBP1) to promote internal tandem duplication of the FLT3 gene during acute myeloid leukemia progression 96 (Figure 1G). Here, STAT3 is linked to acute myeloid leukemia.