TIGAR and esophageal squamous cell carcinoma: Based on these results, we treated KYSE150 and KYSE30 with CB-839 or 5FU/DDP and found that while both treatments significantly suppressed ESCC cell proliferation in dose-dependent manner, ESCC cells with TIGAR overexpression seemed more vulnerable to CB-839 but more resistant to 5FU/DDP remedy than ESCC cells without TIGAR overexpression (Figures 5A-B; Figures S7E-F).