Among 24 hub genes, 5 hub genes performed significant prognostic value (p < 0.01) in PAAD, including AURKA (p = 0.0059), CCNA2 (p = 0.0047), CXCL10 (p = 0.0044), ADAM10 (p = 0.00043), and BUB1 (p = 0.0033). The gene discussed is CCNA2; the disease is pancreatic adenocarcinoma.