Of these, four methylation sites including cg05413957 (GRID2IP), cg07020967 (TMEM117), cg10674684 (intergenic region), and cg20100408 (HLA-DP) were selected as the optimal model sites for the prognostic assessment of patient with GC by LASSO regression and multivariate Cox regression analysis. This evidence concerns the gene TMEM117 and gastric cancer.