Bioinformatic analysis revealed an association between TMEM117 downregulation and pancreatic cancer tumorigenesis and metastasis [47], trans-differentiation to mesenchymal cells in breast cancer [48], phenotypic change of normal cells of gliomas [49], and development of malignant lymphoblastic leukemia [50]. The gene discussed is TMEM117; the disease is familial pancreatic carcinoma.