WB detection in CD73-overexpressed GC cells confirmed that phosphorylation of LIM kinase (p-LIMK) and cofilin (p-cofilin), direct substrates of GTP-bound RhoA, were reduced by activation of RICS, indicating suppression effects of RICS in RhoA activity (Fig. 4d). The gene discussed is LIMK1; the disease is gastric cancer.