A group of ARHGAPs have been characterized to facilitate actin polymerization and cancer cell morphology via GAP activity in Rho GTPases, including Rho, Rac, and Cdc42 subfamilies, and is responsible for modulation of pivotal pathways during the cancer metastasis like p53, Hippo, and PKA signaling24. The gene discussed is AKT1; the disease is cancer.