Functional and mechanistic studies suggested that CD73 triggering adenosinergic signaling acted as a regulator of cytoskeleton by crosstalk with intracellular RICS, which inhibited phosphorylation of RhoA-LIMK-cofilin pathway and activated β-catenin-induced EMT process via a direct interaction, ultimately resulting in metastasis property of GC (Fig. 7e). This evidence concerns the gene CFL1 and gastric cancer.