The second candidate gene, GABRA1 has been associated with early infantile epileptic encephalopathy (EIEE19; MIM: 615744) and juvenile myoclonic epilepsy (EJM4, EJM5; MIM: 611136) and, therefore, became the primary putative candidate gene based on clinical phenotype. This evidence concerns the gene CACNB4 and early-infantile DEE.