The second candidate gene, GABRA1 has been associated with early infantile epileptic encephalopathy (EIEE19; MIM: 615744) and juvenile myoclonic epilepsy (EJM4, EJM5; MIM: 611136) and, therefore, became the primary putative candidate gene based on clinical phenotype. The gene discussed is CACNB4; the disease is juvenile myoclonic epilepsy.