VEGFA and ocular melanoma: Figure 4D shows that both COCl2 and DMOG augmented VEGF release but DMOG has a much more striking impact. In all three groups of treatment conditions (Complete EGM2, CTR, and OM), DMOG led to a significant increase of VEGF compared to 1% O2 and COCl2 (p < 0.05). This finding could imply that in terms of using hypoxia-induced chemicals to increase angiogenesis, DMOG could be a better option than COCl2.