TP53 and neoplasm: For example, mut-p53 can interact with NF-Y, SREBP, VDR, Sp1, ETS2, E2F4, YAP, and NRF2 transcription factors, and enhance or decrease their transcription activities to promote tumor progression and spread [8,9,10,11,12,15,16,17,18,19] (Figure 1).