In HNSCC patients, high levels of lncMIR205HG are associated with tumoral samples that depend upon the expression of mut-p53 proteins [92], whereas although mut-p53 forms transcriptional oncogenic complexes with the YAP cofactor [18], it is evident that a type of feedback is established within a mut-p53/lncRNAs/miRNAs network for the homeostasis of pro-proliferative transcriptional complexes driven by mutant p53 in cancer cells. The gene discussed is TP53; the disease is cancer.