Recently, a multi-omic approach combining DNA interactome, transcriptome, and proteome analysis have brought out a “core” and specific properties common to the different mutant p53 proteins that suggests an influence of mut-p53 on the protein content of cancer cells that goes beyond the control of transcriptional mechanisms to the proteasome-mediated alteration of the proteome [103]. The gene discussed is TP53; the disease is cancer.