It has been shown that mut-p53 increased intrinsic resistance to chemotherapies down-regulating miR-30c with the consequent up-regulation of DNA repair protein, Fanconi anemia complementation group F protein (FANCF), and the translation synthesis DNA polymerase REV1 protein, two factors that are frequently abundant in the context of mut-p53-breast cancer [65]. The gene discussed is TP53; the disease is breast cancer.