As GOF TP53 mutations are associated with tumors under high replicative stress, high genomic instability, and reduced patient survival, it was very recently reported that mut-p53, by the induction of miR-205-5p expression, is able to repress the expression of genes involved in DNA repair of DNA double-strand breaks in head and neck squamous cell carcinoma (HNSCC) (BRCA1 and RAD17) [49]. This evidence concerns the gene RAD17 and head and neck squamous cell carcinoma.