IL1A and liver cancer: For example, some reports associated INDEL mutations at miRNA binding sites in genes related to gastric cancer and other tumors, as reported by Gao et al., who observed an indel polymorphism within the 3’UTR region of the gene (which is associated with liver cancer in Chinese population) that affect the binding of miR-122 and miR-378, influencing the regulation of interleukin 1 alpha (IL-1a) by these miRNAs [121].