FHIT and neoplasm: For instance, FRAgile site 3B (FRA3B) and FRA16D CFSs co-localize with two tumor suppressor genes, the fragile histidine triad (FHIT) gene and the WW domain-containing oxidoreductase (WWOX), respectively [7,8], two genes known for their involvement in chromosomal aberrations and found mutated in different type of tumors [9,10].