Still, they are important to recognize, since some of them are associated with germline mutations or syndromes, including Anaplastic Lymphoma Kinase (ALK)-rearranged-RCC (ALK-RCC), Succinate Dehydrogenase-deficient renal cell carcinomas (SDH-RCC), and Hereditary Leiomyomatosis and Renal Cell Carcinoma-RCC (HLRCC-RCC) [59]. The gene discussed is ALK; the disease is hereditary clear cell renal cell carcinoma.