MiT-RCCs harbor translocations that lead to fusions with different genes: Xp11.2 tRCCs harbor translocations of the Transcription Factor E3 (TFE3) gene with different fusion partners (Table 7), and t(6;11) RCC fuses Transcription Factor EB (TFEB) to MALAT1. Since some antibodies can be technically challenging and sensitive to suboptimal fixation (e.g., TFE3 and TFEB) [72], Fluorescent in situ hybridization (FISH) break apart probes detecting the TFE3 [73], TFEB [74], and ALK translocation [67,75,76] can be used (Table 7), although false negative results have been reported. The gene discussed is TFEB; the disease is renal cell carcinoma.