Moreover, sEV derived from oral cancer cells contained a variety of HSPs, including HSP90α (HSP90AA1), HSP90β, TRAP1 (mitochondrial HSP90), HSP105, HSP70 (HSP72/HSPA1A and HSP70B’/HSPA6), GRP78/HSPA5 (ER chaperone), and HSC70 [20]. The gene discussed is HSPA5; the disease is lip and oral cavity carcinoma.