Although early studies have suggested that IL-6 induced rat HO-1 gene expression through the JAK/STAT pathway in hepatocytes [24] and the induction of IL-6 on human HO-1 gene expression in the human hepatoma cells during acute-phase reaction [25], the potential crosstalk between IL-6 and HO-1 has not yet been studied. This evidence concerns the gene IL6 and hepatocellular carcinoma.