In line with this hypothesis, it is known that patients with NK-type chronic lymphoproliferative disease of granular lymphocytes (NK-LGLs) can develop autoimmune disorders, such as cytopenias, vasculitic syndromes and neuropathy [70], suggesting that autoaggressive NK-LGLs might specifically target hematopoietic cells and endothelial cells known to express CD48 antigen. This evidence concerns the gene CD48 and neuropathy.