IL-31 and IL-33 are newly discovered mediators of inflammation that are reported to play a significant role in the pathogenesis of chronic inflammatory diseases including atopic dermatitis, pruritus, inflammatory bowel diseases, and autoimmune diseases such as bronchial asthma, systemic lupus erythematosus, and anaphylactic shock [5,6,7]. The gene discussed is IL31; the disease is Pruritus.