ENSG00000251605 and acute lymphoblastic leukemia: We found that GC-resistant T-ALL cells display altered splicing (in particular intron retention) of multiple genes involved in oxidative phosphorylation, in particular components of ubiquinol-cytochrome c reductase and NADH dehydrogenase complex (which promotes DNA damage-induced apoptosis through the production of reactive oxygen species (ROS)) [51].