PRNP and scrapie: However, although the amounts of PrPSc might be much higher in scrapie or CWD it does not seem an exclusive trait of these prion diseases as demonstrated by the detection of protease-resistant PrP forms in urine of BSE-affected cattle, sCJD or gCJD-affected patients as well as in intracerebrally scrapie-infected hamsters in pre-clinical stages of disease [278].