The published studies on IP6K1 used a high fat diet without added cholesterol or fructose [22,29,40,42] that develops obesity and NAFL, but not a full spectrum of NAFLD/NASH that includes inflammation, ballooning, stellate cell activation and fibrosis [53,54,55,56,244]. This evidence concerns the gene IP6K1 and obesity due to melanocortin 4 receptor deficiency.