Thus, Western diet-fed apolipoprotein E (ApoE) or low density lipoprotein receptor (Ldlr) knockout mice, which develop metabolic syndrome and atherosclerosis, also develop NAFLD/NASH [246,247,248,249,250,251,252,253,254,255,256,257,258,259,260,261]. Here, APOE is linked to metabolic dysfunction-associated steatotic liver disease.