Figure 4 summarizes the analysis of apoptotic (cytoplasmic caspase-3 expression, Bax and Bcl-2), proliferative (Ki67 expression), and angiogenic markers (VEGF and VEGFR-2 expression), as well as the antioxidant effect (MDA levels) in rat mammary carcinoma cells in vivo. Here, CASP3 is linked to breast carcinoma.