In RUNT KO melanoma cells, reduced expression of genes involved in metastatic processes (e.g., CD31, MMP9 and VEGFA) was observed, and genes involved in promoting bone metastasis, such as IBSP (coding for bone sialoprotein) and SPP1 (coding for osteopontin) [15], were downregulated. The gene discussed is VEGFA; the disease is melanoma.