In particular, PTHrP exerts its role in cancer progression and metastases in autocrine (enhancing proliferation, survival and apoptosis resistance), paracrine (inducing RANKL(Receptor Activator of Nuclear Factor Kappa B Ligand) expression in osteoblasts to activate bone resorption) and intracrine (promoting survival, anoikis evasion and cell invasion) manners [17]. This evidence concerns the gene PTHLH and cancer.