For the preneoplastic (MCF10.AT1) to DCIS (MCF10.DCIS) transition in breast cancer development, GNF2_NPM1 and GGCAGTG_MIR3243P were the top two pathway networks that were found to be significantly dysregulated (by at least twofold; Figure 8C). The gene discussed is NPM1; the disease is breast carcinoma.