EIF2AK3 and Cerebral ischemia: The PERK/eIF2α pathway and its downstream regulators have been shown to be upregulated in studies related to cerebral ischemia [116], recurrent febrile seizures [117], and traumatic brain injury [118], and the involvement of PERK has been previously documented in a brain ischemia and reperfusion model, with the help of eIF2α.