MAPT and tauopathy: Transmission of protopathic seeds, characteristic for prion disease, have been found in in vivo research including Aβ transmission in transgenic mice, mutant P301S tau transmission in transgenic mice and from human tauopathies into transgenic mice, α-synuclein transmission in transgenic mice using synthetic fibrils and human MSA brain extracts, and TDP43 transmission in transgenic mice using human brain-derived FTLD-TDP extracts [124,125,126,127].