It has been demonstrated that deuterium was incorporated into docosahexaenoic acid (DHA) and arachidonic acid (ARA) in the hippocampus and cerebral cortex in amyloid precursor protein (APP)/presenilin-1 (PS1) double mutant transgenic mice fed a D-PUFA diet, as well as the D-PUFA diet being strictly correlated with significant decrease in products of LPO, including both F2-IsoPs and F4-neuroprostanes, in brain tissue of the mouse model of AD. This evidence concerns the gene PSEN1 and Alzheimer disease.