It has also been reported that tau, similarly to prions, propagates numerous conformations from different sporadic tauopathies in vitro as well as initiates distinct pathologies in vivo in mouse models demonstrating human diversity of tauopathies Interestingly, the mentioned conformations of tau are transmissible and may be passaged both in in vitro and in vivo models [116,117,118,119]. This evidence concerns the gene MAPT and tauopathy.