Among genes most frequently associated with PD, leucine-rich repeat kinase 2 (LRRK2), synuclein alpha (SNCA), vacuolar protein sorting-associated protein 35 (VPS35), and glucosylceramidase beta (GBA) can be indicated, mutations of which occur in autosomal dominant PD (ADPD), as well as parkin RBR E3 ubiquitin protein ligase (Parkin), pten-induced putative kinase 1 (PINK1), and protein deglycase (DJ1), linked to early-onset autosomal recessive PD (ARPD) [57,62]. The gene discussed is VPS35; the disease is Parkinson disease.