Beclin-1, which is indispensable to the recruitment of other autophagic proteins during the expansion of pre-autophagosomal membrane, and microtubule-associated protein light chain 3 (LC3) proteins increased in cerebral cortex, which indicated that autophagy was activated after the cerebral ischemia-reperfusion injury [55]. Here, BECN1 is linked to Cerebral ischemia.